Familial Mediterranean Fever (FMF) and renal disease: first report on 29 Sicilian patients
نویسندگان
چکیده
There were no significant differences (age at onset, initial dose of colchicine and serum amyloid A levels) in the two groups. The FMF patients with elevated proteinuria showed a short time between the age of onset and the starting of colchicine than ones with normal proteinuria. Two patients with pathological proteinuria did not have MEFV gene mutations. After the increase of colchicine, there was the complete resolution of proteinuria in all patients. Conclusion Colchicine is an effective medication in the prevention and treatment of amyloidosis; In contrast to other reported studies, there was no correlation between amyloidosis and M694V homozygosity in this cohort. Ten patients of our population who received a delayed diagnosis (median age of diagnosis 40 years) don't show renal damage. from 15th Paediatric Rheumatology European Society (PreS) Congress London, UK. 14–17 September 2008
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